Research workbench

Crystal structure of human eukaryotic translation initiation factor EIF5A

Analyse Crystal structure of human eukaryotic translation initiation factor EIF5A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3CPF
Type: protein
Length: 258 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 5A-1
UniProt: P63241
Ligands: UNX

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 5A-1	protein	132	12% helix, 55% strand	P63241
B	Eukaryotic translation initiation factor 5A-1	protein	126	12% helix, 48% strand	P63241

Ligands and binding sites

UNX · Unknown atom or ion · ion · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 130 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3CPF · Crystal structure of human eukaryotic translation initiation factor EIF5A · the same entry in another collection · chain A against A, TM-score 1.00
P63241 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 5A-1… · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63241
Elsewhere: RCSB PDB 3CPF · PDBe 3CPF · UniProt P63241

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.