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Crystal structure of cholesterol oxidase complexed with a steroid substrate. implications for FAD dependent alcohol oxidases

Analyse Crystal structure of cholesterol oxidase complexed with a steroid substrate.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3COX
Type: protein
Length: 500 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cholesterol oxidase
EC: 1.1.3.6
UniProt: P22637
Ligands: FAD
Pockets: 2 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cholesterol oxidase (EC 1.1.3.6)	protein	500	27% helix, 23% strand	P22637

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	633	0.86	0.90	73	FAD
2	51	0.26	0.74	18	empty

Compared structures

3COX · Crystal structure of cholesterol oxidase complexed with a steroid substrate. implications… · the same entry in another collection · chain A against A, TM-score 1.00
P22637 · AlphaFold monomer V2.0 prediction for cholesterol oxidase (P22637) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22637
Elsewhere: RCSB PDB 3COX · PDBe 3COX · UniProt P22637

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