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Crystal structure of P38DELTA kinase

Analyse Crystal structure of P38DELTA kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3COI
Type: protein
Length: 344 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitogen-activated protein kinase 13
EC: 2.7.11.24
UniProt: O15264
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitogen-activated protein kinase 13 (EC 2.7.11.24)	protein	344	37% helix, 17% strand	O15264

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	289	0.66	0.82	35	empty
2	64	0.54	0.87	25	empty
3	54	0.32	0.77	12	empty
4	61	0.29	0.75	12	empty
5	51	0.29	0.75	12	empty

Compared structures

3COI · Crystal structure of p38delta kinase · the same entry in another collection · chain A against A, TM-score 1.00
O15264 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 13 (O15264) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15264
Elsewhere: RCSB PDB 3COI · PDBe 3COI · UniProt O15264

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