Research workbench
The DVL2 PDZ domain in complex with the N3 inhibitory peptide
Analyse The DVL2 PDZ domain in complex with the N3 inhibitory peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CC0
- Type
- protein
- Length
- 307 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dishevelled-2
- UniProt
- O14641
- Pockets
- 1 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dishevelled-2 | protein | 106 | 15% helix, 37% strand | O14641 |
| B | Dishevelled-2 | protein | 103 | 16% helix, 36% strand | O14641 |
| C | Dishevelled-2 | protein | 98 | 17% helix, 40% strand | O14641 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 567 | 0.69 | 0.78 | 49 | empty |
Interfaces
3 interfaces between chains.
- B–C · 739 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 731 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 700 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3CC0 · The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide · the same entry in another collection · chain A against A, TM-score 1.00
- O14641 · AlphaFold monomer V2.0 prediction for segment polarity protein dishevelled homolog dvl-2… · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14641
- Elsewhere: RCSB PDB 3CC0 · PDBe 3CC0 · UniProt O14641
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.