Research workbench

Chalcone isomerase

Analyse Chalcone isomerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1EYP
Type: protein
Length: 419 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chalcone-flavonone isomerase 1
EC: 5.5.1.6
UniProt: P28012
Pockets: 4 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chalcone-flavonone isomerase 1 (EC 5.5.1.6)	protein	212	38% helix, 31% strand	P28012
B	Chalcone-flavonone isomerase 1 (EC 5.5.1.6)	protein	207	38% helix, 28% strand	P28012

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	723	0.84	0.87	79	empty
2	191	0.69	0.87	26	empty
3	59	0.28	0.73	14	empty
4	64	0.28	0.73	26	empty

Interfaces

1 interface between chains.

A–B · 921 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

1EYP · Chalcone isomerase · the same entry in another collection · chain A against A, TM-score 1.00
P28012 · AlphaFold monomer V2.0 prediction for chalcone--flavanone isomerase 1 (P28012) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28012
Elsewhere: RCSB PDB 1EYP · PDBe 1EYP · UniProt P28012

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.