UniProt P28012
Chalcone--flavonone isomerase 1 (P28012)
Chalcone--flavonone isomerase 1 (UniProt P28012), EC 5.5.1.6: 18 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 66 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P28012
- Protein
- Chalcone--flavonone isomerase 1
- EC
- 5.5.1.6
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 66 · 18 records with a druggable one
Structures
19 records of P28012 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EYP | Chalcone isomerase | x-ray diffraction | A, B | — | 4 (best 0.84) |
| 1EYP | Chalcone isomerase | x-ray diffraction | A, B | — | 4 (best 0.84) |
| 1EYQ | Chalcone isomerase and naringenin | x-ray diffraction | A, B | SO4, NAR | 3 (best 0.84) |
| 1EYQ | Chalcone isomerase and naringenin | x-ray diffraction | A, B | SO4, NAR | 3 (best 0.84) |
| 1FM7 | Chalcone isomerase complexed with 5-deoxyflavanone | x-ray diffraction | A, B | SO4, DFV | 1 (best 0.85) |
| 1FM7 | Chalcone isomerase complexed with 5-deoxyflavanone | x-ray diffraction | A, B | SO4, DFV | 1 (best 0.85) |
| 1FM8 | Chalcone isomerase complexed with 5,4'-dideoxyflavanone | x-ray diffraction | A, B | SO4, DDC | 2 (best 0.85) |
| 1FM8 | Chalcone isomerase complexed with 5,4'-dideoxyflavanone | x-ray diffraction | A, B | SO4, DDC | 2 (best 0.85) |
| 1JEP | Chalcone Isomerase Complexed with 4'-hydroxyflava | x-ray diffraction | A, B | SO4, DFL | 3 (best 0.83) |
| 1JEP | Chalcone isomerase complexed with 4'-hydroxyflavanone | x-ray diffraction | A, B | SO4, DFL | 3 (best 0.83) |
| 1JX0 | Chalcone Isomerase--Y106F mutant | x-ray diffraction | A, B | SO4, DFV | 4 (best 0.83) |
| 1JX0 | Chalcone isomerase--Y106F mutant | x-ray diffraction | A, B | SO4, DFV | 4 (best 0.83) |
| 1JX1 | Chalcone Isomerase--T48A mutant | x-ray diffraction | A, B, C, D, E, F | SO4, DFV | 10 (best 0.69) |
| 1JX1 | Chalcone isomerase--T48A mutant | x-ray diffraction | A, B, C, D, E, F | SO4, DFV | 10 (best 0.69) |
| 6CJN | Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95T mutation | x-ray diffraction | A, B | SO4 | 2 (best 0.85) |
| 6CJN | Crystal structure of chalcone isomerase from medicago sativa with the G95T mutation | x-ray diffraction | A, B | SO4 | 2 (best 0.85) |
| 6CJO | Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95S mutation. | x-ray diffraction | A, B | SO4 | 4 (best 0.84) |
| 6CJO | Crystal structure of chalcone isomerase from medicago sativa with the G95S mutation. | x-ray diffraction | A, B | SO4 | 4 (best 0.84) |
| P28012 | AlphaFold monomer V2.0 prediction for chalcone--flavanone isomerase 1 (P28012) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1FM8 chain A against the predicted model P28012: TM-score 0.97, RMSD 0.96 Å
- 1FM8 chain A against the predicted model P28012: TM-score 0.97, RMSD 0.96 Å
- 1EYQ chain A against the predicted model P28012: TM-score 0.97, RMSD 0.96 Å
- 1EYQ chain A against the predicted model P28012: TM-score 0.97, RMSD 0.96 Å
- 1FM7 chain A against the predicted model P28012: TM-score 0.97, RMSD 0.96 Å
- 1FM7 chain A against the predicted model P28012: TM-score 0.97, RMSD 0.96 Å
- 1JEP chain A against the predicted model P28012: TM-score 0.97, RMSD 0.97 Å
- 1JEP chain A against the predicted model P28012: TM-score 0.97, RMSD 0.97 Å
- 1JX0 chain B against the predicted model P28012: TM-score 0.97, RMSD 0.95 Å
- 1JX0 chain B against the predicted model P28012: TM-score 0.97, RMSD 0.95 Å
Elsewhere
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