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Ligand · DFL

DFL · 2-(4-hydroxy-phenyl)-chroman-4-one

DFL, 2-(4-hydroxy-phenyl)-chroman-4-one (C15 H12 O3, 240.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
DFL
Formula
C15 H12 O3
Class
ligand
Structures
4
PDB entries
2

Binding sites

DFL in 4 structures; the first of them:

  • 1JEP · Chalcone Isomerase Complexed with 4'-hydroxyflava · DFL A501 · binds ARG36, GLY37, LEU38, PHE47, THR48, ILE50, LEU101, GLU105 and 6 more
  • 4KZQ · Crystal structure of human tankyrase 2 in complex with 4' -hydroxy flavone · DFL A1201 · binds PHE1030, HIS1031, GLY1032, SER1033, ALA1049, TYR1050, TYR1060, PHE1061 and 6 more
  • 1JEP · Chalcone isomerase complexed with 4'-hydroxyflavanone · DFL A501 · binds ARG36, GLY37, LEU38, PHE47, THR48, ILE50, LEU101, GLU105 and 6 more
  • 4KZQ · Crystal structure of human tankyrase 2 in complex with 4' -hydroxy flavone · DFL A1201 · binds PHE1030, HIS1031, GLY1032, SER1033, ALA1049, TYR1050, TYR1060, PHE1061 and 6 more

Residues it binds most

TYR 8, PHE 8, GLU 8, ILE 8, LEU 4, LYS 8, SER 4, THR 4, ALA 4, GLY 6 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • ZN · Zinc ion

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