Research workbench
Structure of the HSP110:HSC70 nucleotide exchange complex
Analyse Structure of the HSP110:HSC70 nucleotide exchange complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3C7N
- Type
- protein
- Length
- 1,189 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock protein homolog SSE1; Heat shock cognate
- UniProt
- P32589, P19120
- Ligands
- ADP, BEF, MG, SO4, CL
- Pockets
- 16 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock protein homolog SSE1 | protein | 649 | 34% helix, 30% strand | P32589 |
| B | Heat shock cognate | protein | 540 | 31% helix, 31% strand | P19120 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- BEF · Beryllium trifluoride ion · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
- CL · Chloride ion · ion · 3 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1127 | 0.84 | 0.85 | 117 | SO4, CL |
| 2 | 363 | 0.78 | 0.89 | 51 | MG, SO4, BEF, ADP |
| 3 | 499 | 0.75 | 0.83 | 52 | empty |
| 4 | 297 | 0.72 | 0.86 | 46 | MG, ADP |
| 5 | 237 | 0.70 | 0.85 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 3012 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 3C7N · Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P32589 · AlphaFold monomer V2.0 prediction for heat shock protein homolog SSE1 (P32589) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P19120 · AlphaFold monomer V2.0 prediction for heat shock cognate 71 kda protein (P19120) · a predicted model of the same protein · chain B against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32589
- Every structure of UniProt P19120
- Elsewhere: RCSB PDB 3C7N · PDBe 3C7N · UniProt P32589 · UniProt P19120
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