Research workbench
Cask cam-kinase domain- 3'-AMP complex, P212121 form
Analyse Cask cam-kinase domain- 3'-AMP complex, P212121 form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3C0I
- Type
- protein
- Length
- 298 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peripheral plasma membrane protein cask
- EC
- 2.7.11.1
- UniProt
- O14936
- Ligands
- 3AM
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peripheral plasma membrane protein cask (EC 2.7.11.1) | protein | 298 | 43% helix, 18% strand | O14936 |
Ligands and binding sites
- 3AM · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 500 | 0.71 | 0.80 | 48 | 3AM |
| 2 | 83 | 0.42 | 0.79 | 17 | empty |
| 3 | 125 | 0.41 | 0.75 | 30 | empty |
Compared structures
- 3C0I · CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form · the same entry in another collection · chain A against A, TM-score 1.00
- O14936 · AlphaFold monomer V2.0 prediction for peripheral plasma membrane protein cask (O14936) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14936
- Elsewhere: RCSB PDB 3C0I · PDBe 3C0I · UniProt O14936
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