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Crystal structure of homomeric yeast LSM3 exhibiting novel octameric ring organisation

Analyse Crystal structure of homomeric yeast LSM3 exhibiting novel octameric ring… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3BW1
Type
protein
Length
172 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
U6 snrna-associated sm-like protein LSM3
UniProt
P57743
Ligands
SO4
Pockets
1 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 49% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BU6 snrna-associated sm-like protein LSM3protein8616% helix, 49% strandP57743

Ligands and binding sites

  • SO4 · Sulfate ion · ion · chains B
  • MPD · (4S)-2-methyl-2,4-pentanediol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1550.460.8415empty

Interfaces

1 interface between chains.

  • A–B · 1000 Ų buried · 15 hydrogen bonds · protein-protein

Compared structures

  • 3BW1 · Crystal structure of homomeric yeast Lsm3 exhibiting novel octameric ring organisation · the same entry in another collection · chain A against A, TM-score 1.00
  • P57743 · AlphaFold monomer V2.0 prediction for U6 snrna-associated sm-like protein LSM3 (P57743) · a predicted model of the same protein · chain A against A, TM-score 0.82

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