Research workbench
Crystal structure of C-cbl-tkb domain complexed with its binding motif in SPROUTY4
Analyse Crystal structure of C-cbl-tkb domain complexed with its binding motif in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BUN
- Type
- protein
- Length
- 311 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 13-meric peptide from protein sprouty homolog 4; E3 ubiquitin-protein ligase cbl
- EC
- 6.3.2.-
- UniProt
- Q9C004, P22681
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 13-meric peptide from protein sprouty homolog 4 | protein | 7 | 0% helix, 14% strand | Q9C004 |
| B | E3 ubiquitin-protein ligase cbl (EC 6.3.2.-) | protein | 304 | 59% helix, 8% strand | P22681 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.47 | 0.80 | 21 | empty |
| 2 | 57 | 0.42 | 0.82 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 564 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 3BUN · Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 · the same entry in another collection · chain A against A, TM-score 1.00
- P22681 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase cbl (P22681) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q9C004 · AlphaFold monomer V2.0 prediction for protein sprouty homolog 4 (Q9C004) · a predicted model of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C004
- Every structure of UniProt P22681
- Elsewhere: RCSB PDB 3BUN · PDBe 3BUN · UniProt Q9C004 · UniProt P22681
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