UniProt P22681
E3 ubiquitin-protein ligase CBL (P22681)
E3 ubiquitin-protein ligase CBL (UniProt P22681), EC 2.3.2.27: 60 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P22681
- Protein
- E3 ubiquitin-protein ligase CBL
- EC
- 2.3.2.27
- Experimental structures
- 60
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 12 · 1 record with a druggable one
Structures
61 records of P22681 in the MolNFT archive: 60 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B47 | Structure of the N-terminal domain of cbl in complex with its binding site in zap-70 | x-ray diffraction | A, B, C | — | — |
| 1B47 | Structure of the N-terminal domain of cbl in complex with its binding site in zap-70 | x-ray diffraction | A, B, C | — | — |
| 1FBV | Structure of a cbl-UBCH7 complex: ring domain function in ubiquitin-protein ligases | x-ray diffraction | A | — | — |
| 1FBV | Structure of a cbl-UBCH7 complex: ring domain function in ubiquitin- protein ligases | x-ray diffraction | A | — | — |
| 1YVH | Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide | x-ray diffraction | A | — | — |
| 1YVH | Crystal structure of the C-cbl tkb domain in complex with the aps ptyr-618 phosphopeptide | x-ray diffraction | A | — | — |
| 2CBL | N-terminal domain of cbl in complex with its binding site on zap-70 | x-ray diffraction | A | — | — |
| 2CBL | N-terminal domain of cbl in complex with its binding site on zap-70 | x-ray diffraction | A | — | — |
| 2JUJ | Solution Structure of the UBA domain from c-Cbl | solution nmr | A | — | — |
| 2JUJ | Solution structure of the uba domain from C-cbl | solution nmr | A | — | — |
| 2K4D | E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity | solution nmr | A | — | — |
| 2K4D | E2-C-cbl recognition is necessary but not sufficient for ubiquitination activity | solution nmr | A | — | — |
| 2OO9 | crystal structure of the UBA domain from human c-Cbl ubiquitin ligase | x-ray diffraction | A, B, C | — | — |
| 2OO9 | Crystal structure of the uba domain from human C-cbl ubiquitin ligase | x-ray diffraction | A, B, C | — | — |
| 2Y1M | Structure of native c-Cbl | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2Y1M | Structure of native C-cbl | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2Y1N | Structure of c-Cbl-ZAP-70 peptide complex | x-ray diffraction | A, C | — | — |
| 2Y1N | Structure of C-cbl-zap-70 peptide complex | x-ray diffraction | A, C | — | — |
| 3BUM | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2 | x-ray diffraction | B | — | — |
| 3BUM | Crystal structure of C-cbl-tkb domain complexed with its binding motif in SPROUTY2 | x-ray diffraction | B | — | — |
| 3BUN | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 | x-ray diffraction | B | — | — |
| 3BUN | Crystal structure of C-cbl-tkb domain complexed with its binding motif in SPROUTY4 | x-ray diffraction | B | — | — |
| 3BUO | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' | x-ray diffraction | B, D | — | — |
| 3BUO | Crystal structure of C-cbl-tkb domain complexed with its binding motif in EGF receptor' | x-ray diffraction | B, D | — | — |
| 3BUW | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk | x-ray diffraction | B, D | — | — |
| 3BUW | Crystal structure of C-cbl-tkb domain complexed with its binding motif in syk | x-ray diffraction | B, D | — | — |
| 3BUX | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met | x-ray diffraction | B, D | — | — |
| 3BUX | Crystal structure of C-cbl-tkb domain complexed with its binding motif in C-met | x-ray diffraction | B, D | — | — |
| 3OB1 | Crystal structure of c-Cbl TKB domain in complex with double phosphorylated Spry2 peptide | x-ray diffraction | B | — | — |
| 3OB1 | Crystal structure of C-cbl tkb domain in complex with double phosphorylated SPRY2 peptide | x-ray diffraction | B | — | — |
| 3OB2 | Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide | x-ray diffraction | B | — | — |
| 3OB2 | Crystal structure of C-cbl tkb domain in complex with double phosphorylated EGFR peptide | x-ray diffraction | B | — | — |
| 3PLF | Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain | x-ray diffraction | B, D | — | — |
| 3PLF | Reverse binding mode of metrd peptide complexed with C-cbl tkb domain | x-ray diffraction | B, D | — | — |
| 4A49 | Structure of phosphoTyr371-c-Cbl-UbcH5B complex | x-ray diffraction | A | — | — |
| 4A49 | Structure of PHOSPHOTYR371-C-cbl-UBCH5B complex | x-ray diffraction | A | — | — |
| 4A4B | Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex | x-ray diffraction | A | — | — |
| 4A4B | Structure of modified PHOSPHOTYR371-C-cbl-UBCH5B-zap-70 complex | x-ray diffraction | A | — | — |
| 4A4C | Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex | x-ray diffraction | A | — | — |
| 4A4C | Structure of PHOSPHOTYR371-C-cbl-UBCH5B-zap-70 complex | x-ray diffraction | A | — | — |
| 4GPL | Structure of Cbl(TKB) bound to a phosphorylated pentapeptide | x-ray diffraction | B | — | — |
| 4GPL | Structure of CBL(TKB) bound to a phosphorylated pentapeptide | x-ray diffraction | B | — | — |
| 5HKW | Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution | x-ray diffraction | A, B, C | NA | — |
| 5HKW | Crystal structure of apo C-cbl tkbd refined to 2.25 a resolution | x-ray diffraction | A, B, C | — | — |
| 5HKX | Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution | x-ray diffraction | A | ZN, NA | — |
| 5HKX | Crystal structure of C-cbl tkbd-ring domains (Y371E mutant) refined to 1.85 a resolution | x-ray diffraction | A | — | — |
| 5HKY | Crystal structure of c-Cbl TKBD domain in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8A… | x-ray diffraction | A | CL, NA | — |
| 5HKY | Crystal structure of C-cbl tkbd domain in complex with SPRY2 peptide (36-60, PY55) refined to 1.8A… | x-ray diffraction | A | — | — |
| 5HKZ | Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (36-60, pY55) Refined to 1.8 A… | x-ray diffraction | A | NA | — |
| 5HKZ | Crystal structure of C-cbl tkbd in complex with SPRY2 peptide (36-60, PY55) refined to 1.8 a… | x-ray diffraction | A | — | — |
| 5HL0 | Crystal Structure of c-Cbl TKBD in complex with SPRY2 peptide (54-60, pY55) Refined to 2.2A… | x-ray diffraction | A | NA | — |
| 5HL0 | Crystal structure of C-cbl tkbd in complex with SPRY2 peptide (54-60, PY55) refined to 2.2A… | x-ray diffraction | A | — | — |
| 5J3X | Structure of C-cbl Y371F | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5O76 | Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant | x-ray diffraction | A, C | ZN, CA | 12 (best 0.73) |
| 5O76 | Structure of PHOSPHOY371 C-cbl in complex with ZAP70-peptide and UBV.PCBL ubiquitin variant | x-ray diffraction | A, C | ZN, CA | — |
| 6O02 | Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL | x-ray diffraction | A | — | — |
| 6O02 | Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase cbl | x-ray diffraction | A | — | — |
| 6O03 | Monobody (MC17) bound to tyrosine kinase binding domain of E3 ubiquitin ligase cbl | x-ray diffraction | B, A | — | — |
| 6XAR | Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase… | x-ray diffraction | A, B | CA | — |
| 6XAR | Structure of cbl tyrosine kinase binding domain (tkbd) with C-terminal tail of src-like kinase… | x-ray diffraction | A, B | CA | — |
1 record more on the page itself.
Ligands
Experiment against prediction
- 3PLF chain B against the predicted model P22681: TM-score 0.99, RMSD 0.64 Å
- 3PLF chain B against the predicted model P22681: TM-score 0.99, RMSD 0.64 Å
- 3PLF chain D against the predicted model P22681: TM-score 0.99, RMSD 0.68 Å
- 3PLF chain D against the predicted model P22681: TM-score 0.99, RMSD 0.68 Å
- 1YVH chain A against the predicted model P22681: TM-score 0.99, RMSD 0.78 Å
- 1YVH chain A against the predicted model P22681: TM-score 0.99, RMSD 0.78 Å
- 4A4B chain A against the predicted model P22681: TM-score 0.99, RMSD 0.87 Å
- 4A4B chain A against the predicted model P22681: TM-score 0.99, RMSD 0.87 Å
- 3OB2 chain B against the predicted model P22681: TM-score 0.99, RMSD 0.74 Å
- 3OB2 chain B against the predicted model P22681: TM-score 0.99, RMSD 0.74 Å
Elsewhere
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