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E. COLI I690C/G743C meth C-terminal fragment (649-1227)

Analyse E. COLI I690C/G743C meth C-terminal fragment (649-1227) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3BUL
Type: protein
Length: 577 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methionine synthase
EC: 2.1.1.13
UniProt: P13009
Ligands: B12
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methionine synthase (EC 2.1.1.13)	protein	577	48% helix, 14% strand	P13009

Ligands and binding sites

B12 · Cobalamin · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	890	0.75	0.79	94	B12
2	398	0.67	0.80	46	empty
3	415	0.60	0.76	31	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3BUL · E. coli I690C/G743C MetH C-terminal fragment (649-1227) · the same entry in another collection · chain A against A, TM-score 1.00
P13009 · AlphaFold monomer V2.0 prediction for methionine synthase (P13009) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13009
Elsewhere: RCSB PDB 3BUL · PDBe 3BUL · UniProt P13009

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