UniProt P13009
Methionine synthase (P13009)
Methionine synthase (UniProt P13009), EC 2.1.1.13: 19 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P13009
- Protein
- Methionine synthase
- EC
- 2.1.1.13
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 2 · 2 records with a druggable one
Structures
20 records of P13009 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BMT | How a protein binds B12: a 3.O ångström X-ray structure of the B12-binding domains of methionine… | x-ray diffraction | A, B | — | — |
| 1BMT | How a protein binds B12: a 3.O ångström X-ray structure of the B12- binding domains of methionine… | x-ray diffraction | A, B | — | — |
| 1K7Y | E. coli MetH C-terminal fragment (649-1227) | x-ray diffraction | A | — | — |
| 1K7Y | E. COLI meth C-terminal fragment (649-1227) | x-ray diffraction | A | — | — |
| 1K98 | AdoMet complex of MetH C-terminal fragment | x-ray diffraction | A | — | — |
| 1K98 | Adomet complex of meth C-terminal fragment | x-ray diffraction | A | — | — |
| 1MSK | Methionine synthase (activation domain) | x-ray diffraction | A | — | — |
| 1MSK | Methionine synthase (activation domain) | x-ray diffraction | A | — | — |
| 3BUL | E. coli I690C/G743C MetH C-terminal fragment (649-1227) | x-ray diffraction | A | — | — |
| 3BUL | E. COLI I690C/G743C meth C-terminal fragment (649-1227) | x-ray diffraction | A | — | — |
| 3IV9 | Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half in a "His-On" conformation | x-ray diffraction | A | — | — |
| 3IV9 | Structure of the B12-dependent methionine synthase (meth) C-teminal half in a "his-on" conformation | x-ray diffraction | A | — | — |
| 3IVA | Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half with AdoHcy bound | x-ray diffraction | A | — | — |
| 3IVA | Structure of the B12-dependent methionine synthase (meth) C-teminal half with adohcy bound | x-ray diffraction | A | — | — |
| 6BDY | Crystal structure of the meth reactivation domain bound to sinefungin | x-ray diffraction | A | — | — |
| 6BM5 | Crystal Structure of the MetH Reactivation Domain bound to AdoMet | x-ray diffraction | A | — | — |
| 6BM5 | Crystal structure of the meth reactivation domain bound to adomet | x-ray diffraction | A | — | — |
| 6BM6 | Crystal Structure of the MetH Reactivation Domain bound to AdoHcy | x-ray diffraction | A | SAH | 1 (best 0.51) |
| 6BM6 | Crystal structure of the meth reactivation domain bound to adohcy | x-ray diffraction | A | SAH | 1 (best 0.51) |
| P13009 | AlphaFold monomer V2.0 prediction for methionine synthase (P13009) | predicted | A | — | — |
Ligands
- SAH · S-adenosyl-L-homocysteine · in 2 records
Experiment against prediction
- 6BM6 chain A against the predicted model P13009: TM-score 0.99, RMSD 0.64 Å
- 6BM6 chain A against the predicted model P13009: TM-score 0.99, RMSD 0.64 Å
- 1MSK chain A against the predicted model P13009: TM-score 0.99, RMSD 0.62 Å
- 1MSK chain A against the predicted model P13009: TM-score 0.99, RMSD 0.62 Å
- 3BUL chain A against the predicted model P13009: TM-score 0.99, RMSD 0.96 Å
- 3BUL chain A against the predicted model P13009: TM-score 0.99, RMSD 0.96 Å
- 6BDY chain A against the predicted model P13009: TM-score 0.99, RMSD 0.69 Å
- 3IVA chain A against the predicted model P13009: TM-score 0.99, RMSD 0.98 Å
- 3IVA chain A against the predicted model P13009: TM-score 0.99, RMSD 0.98 Å
- 6BM5 chain A against the predicted model P13009: TM-score 0.99, RMSD 0.72 Å
Elsewhere
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