Research workbench
Structure of the cytoplasmic beta subunit-T1 assembly of voltage- dependent K channels
Analyse Structure of the cytoplasmic beta subunit-T1 assembly of voltage- dependent K… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1EXB
- Type
- protein
- Length
- 417 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kv BETA2 protein; Potassium channel KV1.1
- UniProt
- P62483, P10499
- Ligands
- NDP
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kv BETA2 protein | protein | 326 | 52% helix, 17% strand | P62483 |
| E | Potassium channel KV1.1 | protein | 91 | 37% helix, 20% strand | P10499 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 317 | 0.70 | 0.83 | 49 | NDP |
| 2 | 166 | 0.49 | 0.77 | 23 | empty |
| 3 | 54 | 0.28 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–E · 370 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1EXB · Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K channels · the same entry in another collection · chain A against A, TM-score 1.00
- P62483 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 1.00
- P10499 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily a member… · a predicted model of the same protein · chain E against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62483
- Every structure of UniProt P10499
- Elsewhere: RCSB PDB 1EXB · PDBe 1EXB · UniProt P62483 · UniProt P10499
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