Research workbench
Crystal structure of HCNK2-SAM/DHYP-SAM complex
Analyse Crystal structure of HCNK2-SAM/DHYP-SAM complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BS5
- Type
- protein
- Length
- 161 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein aveugle; Connector enhancer of kinase suppressor of RAS 2
- UniProt
- Q8ML92, Q8WXI2
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein aveugle | protein | 86 | 77% helix, 0% strand | Q8ML92 |
| B | Connector enhancer of kinase suppressor of RAS 2 | protein | 75 | 72% helix, 0% strand | Q8WXI2 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.32 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 591 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 3BS5 · Crystal Structure of hCNK2-SAM/dHYP-SAM Complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WXI2 · AlphaFold monomer V2.0 prediction for connector enhancer of kinase suppressor of RAS 2… · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q8ML92 · AlphaFold monomer V2.0 prediction for protein aveugle (Q8ML92) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ML92
- Every structure of UniProt Q8WXI2
- Elsewhere: RCSB PDB 3BS5 · PDBe 3BS5 · UniProt Q8ML92 · UniProt Q8WXI2
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