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Human 3-O-sulfotransferase isoform 5 with bound pap

Analyse Human 3-O-sulfotransferase isoform 5 with bound pap in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3BD9
Type: protein
Length: 258 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heparan sulfate glucosamine 3-O-sulfotransferase 5
EC: 2.8.2.23
UniProt: Q8IZT8
Ligands: A3P
Pockets: 1 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23)	protein	258	43% helix, 16% strand	Q8IZT8

Ligands and binding sites

A3P · Adenosine-3'-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	240	0.55	0.77	29	A3P

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3BD9 · human 3-O-sulfotransferase isoform 5 with bound PAP · the same entry in another collection · chain A against A, TM-score 1.00
Q8IZT8 · AlphaFold monomer V2.0 prediction for heparan sulfate glucosamine 3-O-sulfotransferase 5… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IZT8
Elsewhere: RCSB PDB 3BD9 · PDBe 3BD9 · UniProt Q8IZT8

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