UniProt Q8IZT8
Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5 (Q8IZT8)
Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5 (UniProt Q8IZT8), EC 2.8.2.23: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 4 pockets. Binding sites, druggability and experiment…
- UniProt
- Q8IZT8
- Protein
- Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5
- EC
- 2.8.2.23
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 4 · 2 records with a druggable one
Structures
7 records of Q8IZT8 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3BD9 | human 3-O-sulfotransferase isoform 5 with bound PAP | x-ray diffraction | A | — | — |
| 3BD9 | Human 3-O-sulfotransferase isoform 5 with bound pap | x-ray diffraction | A | — | — |
| 7SCD | Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-1 octasaccharide substrate and co-factor… | x-ray diffraction | A | BDP, SGN, A3P | 2 (best 0.68) |
| 7SCD | Ternary complex of fixed-arm trx-3OST5 (I299E) with 8MER-1 octasaccharide substrate and co-factor… | x-ray diffraction | A | BDP, SGN, A3P | — |
| 7SCE | Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-2 octasaccharide substrate and co-factor… | x-ray diffraction | A | IDS, SGN, BDP, A3P | 2 (best 0.71) |
| 7SCE | Ternary complex of fixed-arm trx-3OST5 (I299E) with 8MER-2 octasaccharide substrate and co-factor… | x-ray diffraction | A | IDS, SGN, BDP, A3P | — |
| Q8IZT8 | AlphaFold monomer V2.0 prediction for heparan sulfate glucosamine 3-O-sulfotransferase 5 (Q8IZT8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3BD9 chain A against the predicted model Q8IZT8: TM-score 0.99, RMSD 0.71 Å
- 3BD9 chain A against the predicted model Q8IZT8: TM-score 0.99, RMSD 0.71 Å
- 7SCD chain A against the predicted model P0AA25: TM-score 0.29, RMSD 0.71 Å
- 7SCE chain A against the predicted model P0AA25: TM-score 0.29, RMSD 0.53 Å
- 7SCE chain A against the predicted model Q8IZT8: TM-score 0.71, RMSD 1.64 Å
- 7SCE chain A against the predicted model Q8IZT8: TM-score 0.71, RMSD 1.64 Å
- 7SCD chain A against the predicted model Q8IZT8: TM-score 0.71, RMSD 1.56 Å
- 7SCD chain A against the predicted model Q8IZT8: TM-score 0.71, RMSD 1.56 Å
Elsewhere
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