Research workbench
Complex of T57A substituted drosophila lush protein with ethanol
Analyse Complex of T57A substituted drosophila lush protein with ethanol in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3B88
- Type
- protein
- Length
- 248 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- General odorant-binding protein lush
- UniProt
- O02372
- Ligands
- ETE
- Pockets
- 4 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 68% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | General odorant-binding protein lush | protein | 124 | 68% helix, 2% strand | O02372 |
Ligands and binding sites
- ETE · 2-{2-[2-2-(methoxy-ethoxy)-ethoxy]-ethoxy}-ethanol · ligand · 2 copies · chains A, B
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.79 | 0.92 | 32 | ACT, ETE |
| 2 | 287 | 0.76 | 0.88 | 37 | ETE |
| 3 | 138 | 0.45 | 0.76 | 27 | empty |
| 4 | 96 | 0.35 | 0.74 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 226 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 3B88 · Complex of T57A Substituted Drosophila LUSH Protein with Ethanol · the same entry in another collection · chain A against A, TM-score 1.00
- O02372 · AlphaFold monomer V2.0 prediction for general odorant-binding protein lush (O02372) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O02372
- Elsewhere: RCSB PDB 3B88 · PDBe 3B88 · UniProt O02372
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.