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Crystal structure of alpha-lactalbumin

Analyse Crystal structure of alpha-lactalbumin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3B0O
Type: protein
Length: 240 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-lactalbumin
UniProt: P00709
Ligands: CA
Pockets: 2 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Alpha-lactalbumin	protein	120	44% helix, 12% strand	P00709

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	198	0.50	0.76	32	empty
2	86	0.34	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 425 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

3B0O · Crystal structure of alpha-lactalbumin · the same entry in another collection · chain A against A, TM-score 1.00
P00709 · AlphaFold monomer V2.0 prediction for alpha-lactalbumin (P00709) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00709
Elsewhere: RCSB PDB 3B0O · PDBe 3B0O · UniProt P00709

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