Research workbench
Crystal structure of the chicken cenp-T histone FOLD/CENP-W complex, crystal form I
Analyse Crystal structure of the chicken cenp-T histone FOLD/CENP-W complex, crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3B0C
- Type
- protein
- Length
- 164 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centromere protein T; Centromere protein W
- UniProt
- F1NPG5
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| T | Centromere protein T | protein | 91 | 70% helix, 5% strand | F1NPG5 |
| W | Centromere protein W | protein | 73 | 73% helix, 4% strand | — |
Ligands and binding sites
- CIT · Citric acid · additive · 3 copies · chains T, W
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.51 | 0.81 | 17 | empty |
| 2 | 58 | 0.33 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- T–W · 2374 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 3B0C · Crystal structure of the chicken CENP-T histone fold/CENP-W complex, crystal form I · the same entry in another collection · chain T against T, TM-score 1.00
- F1NPG5 · AlphaFold monomer V2.0 prediction for centromere protein T (F1NPG5) · a predicted model of the same protein · chain T against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F1NPG5
- Elsewhere: RCSB PDB 3B0C · PDBe 3B0C · UniProt F1NPG5
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