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Crystal structure of wild-type LYS48-linked diubiquitin in an open conformation

Analyse Crystal structure of wild-type LYS48-linked diubiquitin in an open conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3AUL
Type: protein
Length: 149 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polyubiquitin-C
UniProt: P0CG48
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polyubiquitin-C	protein	76	24% helix, 33% strand	P0CG48
B	Polyubiquitin-C	protein	73	25% helix, 34% strand	P0CG48

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	113	0.43	0.77	25	empty

Interfaces

1 interface between chains.

A–B · 390 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 isopeptide (isopeptide).

Compared structures

3AUL · Crystal structure of wild-type Lys48-linked diubiquitin in an open conformation · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0CG48
Elsewhere: RCSB PDB 3AUL · PDBe 3AUL · UniProt P0CG48

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