Research workbench
Crystal structure of TOPBP1 BRCT7/8-BACH1 peptide complex
Analyse Crystal structure of TOPBP1 BRCT7/8-BACH1 peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3AL3
- Type
- protein
- Length
- 228 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA topoisomerase 2-binding protein 1; Peptide of fanconi anemia group J protein
- UniProt
- Q92547, Q9BX63
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2-binding protein 1 | protein | 218 | 42% helix, 14% strand | Q92547 |
| B | Peptide of fanconi anemia group J protein | protein | 10 | 0% helix, 0% strand | Q9BX63 |
Ligands and binding sites
- FMT · Formic acid · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 729 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 3AL3 · Crystal Structure of TopBP1 BRCT7/8-BACH1 peptide complex · the same entry in another collection · chain B against B, TM-score 1.00
- Q92547 · AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-binding protein 1 (Q92547) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9BX63 · AlphaFold monomer V2.0 prediction for fanconi anemia group J protein (Q9BX63) · a predicted model of the same protein · chain B against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92547
- Every structure of UniProt Q9BX63
- Elsewhere: RCSB PDB 3AL3 · PDBe 3AL3 · UniProt Q92547 · UniProt Q9BX63
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