UniProt Q92547
DNA topoisomerase 2-binding protein 1 (Q92547)
DNA topoisomerase 2-binding protein 1 (UniProt Q92547): 25 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q92547
- Protein
- DNA topoisomerase 2-binding protein 1
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 18 · 3 records with a druggable one
Structures
26 records of Q92547 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WF6 | The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product | solution nmr | A | — | — |
| 1WF6 | The third BRCA1 C-terminus (brct) domain of similar to S.POMBE RAD4+/CUT5+ product | solution nmr | A | — | — |
| 2XNH | Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1 | x-ray diffraction | A | — | — |
| 2XNH | Structure and function of the RAD9-binding region of the DNA damage checkpoint adaptor TOPBP1 | x-ray diffraction | A | — | — |
| 2XNK | Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1 | x-ray diffraction | A, B, C, D | — | — |
| 2XNK | Structure and function of the RAD9-binding region of the DNA damage checkpoint adaptor TOPBP1 | x-ray diffraction | A, B, C, D | — | — |
| 3AL2 | Crystal Structure of TopBP1 BRCT7/8 | x-ray diffraction | A | — | — |
| 3AL2 | Crystal structure of TOPBP1 BRCT7/8 | x-ray diffraction | A | — | — |
| 3AL3 | Crystal Structure of TopBP1 BRCT7/8-BACH1 peptide complex | x-ray diffraction | A | — | — |
| 3AL3 | Crystal structure of TOPBP1 BRCT7/8-BACH1 peptide complex | x-ray diffraction | A | — | — |
| 3JVE | Crystal Structure of the Sixth BRCT Domain of TopBP1 | x-ray diffraction | A | — | — |
| 3JVE | Crystal structure of the sixth brct domain of TOPBP1 | x-ray diffraction | A | — | — |
| 3OLC | Crystal structure of the N-terminal region of TopBP1 | x-ray diffraction | X | — | — |
| 3OLC | Crystal structure of the N-terminal region of TOPBP1 | x-ray diffraction | X | — | — |
| 3PD7 | Crystal Structure of the Sixth BRCT Domain of Human TopBP1 | x-ray diffraction | A, B | — | — |
| 3PD7 | Crystal structure of the sixth brct domain of human TOPBP1 | x-ray diffraction | A, B | — | — |
| 3UEN | Crystal structure of TopBP1 BRCT4/5 domains | x-ray diffraction | A | — | — |
| 3UEN | Crystal structure of TOPBP1 BRCT4/5 domains | x-ray diffraction | A | — | — |
| 3UEO | Crystal structure of TopBP1 BRCT4/5 domains in complex with a phospho-peptide | x-ray diffraction | A, B, C, D | — | — |
| 3UEO | Crystal structure of TOPBP1 BRCT4/5 domains in complex with a phospho- peptide | x-ray diffraction | A, B, C, D | — | — |
| 6RML | Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide | x-ray diffraction | B, A | — | — |
| 6RMM | Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide | x-ray diffraction | A, B, C, D | — | 7 (best 0.78) |
| 6RMM | Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide | x-ray diffraction | A, B, C, D | — | — |
| 7CMZ | Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8 | x-ray diffraction | A | K, NA | 1 (best 0.51) |
| 7CMZ | Crystal structure of BRCT7/8 in complex with the aps motif of PHF8 | x-ray diffraction | A | K, NA | — |
| Q92547 | AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-binding protein 1 (Q92547) | predicted | A | — | 10 (best 0.54) |
Ligands
Experiment against prediction
- 3UEO chain A against the predicted model Q92547: TM-score 0.99, RMSD 0.48 Å
- 3UEO chain A against the predicted model Q92547: TM-score 0.99, RMSD 0.48 Å
- 3UEO chain C against the predicted model Q92547: TM-score 0.99, RMSD 0.60 Å
- 3UEO chain C against the predicted model Q92547: TM-score 0.99, RMSD 0.60 Å
- 6RMM chain C against the predicted model Q92547: TM-score 0.98, RMSD 0.67 Å
- 6RMM chain C against the predicted model Q92547: TM-score 0.98, RMSD 0.67 Å
- 3UEN chain A against the predicted model Q92547: TM-score 0.98, RMSD 0.79 Å
- 3UEN chain A against the predicted model Q92547: TM-score 0.98, RMSD 0.79 Å
- 2XNK chain A against the predicted model Q92547: TM-score 0.98, RMSD 1.03 Å
- 2XNK chain A against the predicted model Q92547: TM-score 0.98, RMSD 1.03 Å
Elsewhere
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