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Crystal structure of TOPBP1 BRCT7/8

Analyse Crystal structure of TOPBP1 BRCT7/8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3AL2
Type: protein
Length: 220 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA topoisomerase 2-binding protein 1
UniProt: Q92547
Ligands: SO4
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA topoisomerase 2-binding protein 1	protein	220	46% helix, 14% strand	Q92547

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.38	0.75	20	empty
2	52	0.28	0.74	12	empty

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

3AL2 · Crystal Structure of TopBP1 BRCT7/8 · the same entry in another collection · chain A against A, TM-score 1.00
Q92547 · AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-binding protein 1 (Q92547) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92547
Elsewhere: RCSB PDB 3AL2 · PDBe 3AL2 · UniProt Q92547

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