Research workbench
Complex between bmp-2 and two bmp receptor ia ectodomains
Analyse Complex between bmp-2 and two bmp receptor ia ectodomains in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ES7
- Type
- protein
- Length
- 377 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bone morphogenetic protein-2; Bone morphogenetic protein receptor ia
- EC
- 2.7.1.-
- UniProt
- P12643, P36894
- Pockets
- 8 · best druggability 0.47
Structure
x-ray diffraction · 3 distinct chains · 10% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Bone morphogenetic protein-2 | protein | 104 | 14% helix, 45% strand | P12643 |
| B | Bone morphogenetic protein receptor ia (EC 2.7.1.-) | protein | 83 | 7% helix, 35% strand | P36894 |
| D | Bone morphogenetic protein receptor ia (EC 2.7.1.-) | protein | 86 | 7% helix, 34% strand | P36894 |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.47 | 0.76 | 28 | empty |
| 2 | 117 | 0.39 | 0.75 | 25 | empty |
| 3 | 83 | 0.35 | 0.75 | 19 | empty |
| 4 | 89 | 0.34 | 0.74 | 18 | empty |
| 5 | 63 | 0.33 | 0.76 | 15 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1216 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 891 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 888 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 420 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 416 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 17 disulfide (disulfide).
Compared structures
- 1ES7 · Complex between bmp-2 and two bmp receptor ia ectodomains · the same entry in another collection · chain D against D, TM-score 1.00
- P12643 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein 2 (P12643) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P36894 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein receptor type-1A (P36894) · a predicted model of the same protein · chain D against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12643
- Every structure of UniProt P36894
- Elsewhere: RCSB PDB 1ES7 · PDBe 1ES7 · UniProt P12643 · UniProt P36894
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