Research workbench
Structure of human REV7 in complex with a human REV3 fragment in a monoclinic crystal
Analyse Structure of human REV7 in complex with a human REV3 fragment in a monoclinic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ABD
- Type
- protein
- Length
- 418 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD2B; DNA polymerase zeta catalytic subunit
- UniProt
- Q9UI95, O60673
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD2B | protein | 180 | 37% helix, 34% strand | Q9UI95 |
| X | DNA polymerase zeta catalytic subunit | protein | 21 | 33% helix, 19% strand | O60673 |
| B | Mitotic spindle assembly checkpoint protein MAD2B | protein | 195 | 35% helix, 31% strand | Q9UI95 |
| Y | DNA polymerase zeta catalytic subunit | protein | 22 | 32% helix, 18% strand | O60673 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.68 | 0.96 | 19 | empty |
| 2 | 182 | 0.47 | 0.76 | 23 | empty |
| 3 | 53 | 0.31 | 0.77 | 17 | empty |
| 4 | 61 | 0.30 | 0.75 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–X · 1152 Ų buried · 14 hydrogen bonds · protein-protein
- B–Y · 1113 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 667 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3ABD · Structure of human REV7 in complex with a human REV3 fragment in a monoclinic crystal · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UI95 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UI95
- Every structure of UniProt O60673
- Elsewhere: RCSB PDB 3ABD · PDBe 3ABD · UniProt Q9UI95 · UniProt O60673
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