Research workbench
Crystal structure of actin capping protein in complex with the cp- binding motif derived from carmil
Analyse Crystal structure of actin capping protein in complex with the cp- binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3AA0
- Type
- protein
- Length
- 532 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, Q6EDY6
- Ligands
- CO3
- Pockets
- 6 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 270 | 40% helix, 34% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 243 | 39% helix, 36% strand | P14315 |
| C | 21MER peptide from leucine-rich repeat-containing protein 16A | protein | 19 | 21% helix, 0% strand | Q6EDY6 |
Ligands and binding sites
- CO3 · Carbonate ion · ion · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.80 | 0.98 | 24 | empty |
| 2 | 63 | 0.59 | 0.90 | 23 | empty |
| 3 | 155 | 0.54 | 0.80 | 24 | empty |
| 4 | 153 | 0.44 | 0.76 | 22 | empty |
| 5 | 83 | 0.34 | 0.75 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3683 Ų buried · 62 hydrogen bonds · protein-protein
- B–C · 1319 Ų buried · 29 hydrogen bonds · protein-protein
- A–C · 155 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3AA0 · Crystal structure of Actin Capping Protein in complex with the Cp-binding motif derived… · the same entry in another collection · chain A against A, TM-score 1.00
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q6EDY6 · AlphaFold monomer V2.0 prediction for F-actin-uncapping protein LRRC16A (Q6EDY6) · a predicted model of the same protein · chain C against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt Q6EDY6
- Elsewhere: RCSB PDB 3AA0 · PDBe 3AA0 · UniProt P13127 · UniProt P14315 · UniProt Q6EDY6
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