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Mutant a. fulgidus lipase S136A complexed with fatty acid fragment

Analyse Mutant a. fulgidus lipase S136A complexed with fatty acid fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ZYH
Type: protein
Length: 912 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipase, putative
EC: 3.1.1.3
UniProt: O28511
Ligands: R16, CA
Pockets: 7 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lipase, putative (EC 3.1.1.3)	protein	456	26% helix, 29% strand	O28511

Ligands and binding sites

R16 · Hexadecane · ligand · 2 copies · chains A, B
CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	629	0.87	0.91	96	R16
2	740	0.83	0.86	94	R16
3	516	0.69	0.79	69	empty
4	217	0.64	0.83	25	empty
5	198	0.63	0.83	25	empty

Interfaces

1 interface between chains.

A–B · 647 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

2ZYH · mutant A. Fulgidus lipase S136A complexed with fatty acid fragment · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O28511
Elsewhere: RCSB PDB 2ZYH · PDBe 2ZYH · UniProt O28511

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