Research workbench
Structure of the connexin-26 gap junction channel at 3.5 ångström resolution
Analyse Structure of the connexin-26 gap junction channel at 3.5 ångström resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZW3
- Type
- protein
- Length
- 1,206 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gap junction beta-2 protein
- UniProt
- P29033
- Pockets
- 19 · best druggability 0.88
Structure
x-ray diffraction · 1 distinct chain · 66% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Gap junction beta-2 protein | protein | 201 | 66% helix, 5% strand | P29033 |
Pockets
19 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 820 | 0.88 | 0.91 | 129 | empty |
| 2 | 791 | 0.88 | 0.90 | 127 | empty |
| 3 | 359 | 0.82 | 0.91 | 53 | empty |
| 4 | 359 | 0.82 | 0.91 | 58 | empty |
| 5 | 252 | 0.57 | 0.78 | 31 | empty |
Interfaces
6 interfaces between chains.
- B–C · 1704 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 1696 Ų buried · 23 hydrogen bonds · protein-protein
- E–F · 1692 Ų buried · 21 hydrogen bonds · protein-protein
- A–F · 1691 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 1688 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 2ZW3 · Structure of the connexin-26 gap junction channel at 3.5 angstrom resolution · the same entry in another collection · chain F against F, TM-score 1.00
- P29033 · AlphaFold monomer V2.0 prediction for gap junction beta-2 protein (P29033) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29033
- Elsewhere: RCSB PDB 2ZW3 · PDBe 2ZW3 · UniProt P29033
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