Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GLUR5, in complex with a novel selective agonist, dysiherbaine

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 22% strand (DSSP).

Ligands and binding sites

• DYH · (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid · ligand · chains A
• BME · Beta-mercaptoethanol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 2ZNT · Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor… · the same entry in another collection · chain A against A, TM-score 1.00
• P39086 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 1 (P39086) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P39086
• Elsewhere: RCSB PDB 2ZNT · PDBe 2ZNT · UniProt P39086