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Structure of PH0037 protein from pyrococcus horikoshii

Analyse Structure of PH0037 protein from pyrococcus horikoshii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ZKT
Type: protein
Length: 711 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
EC: 5.4.2.1
UniProt: O57742
Ligands: ZN, CA
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)	protein	330	36% helix, 21% strand	O57742
B	2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1)	protein	381	38% helix, 19% strand	O57742

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B
CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	375	0.70	0.83	43	empty
2	380	0.58	0.75	41	empty
3	311	0.54	0.75	35	ZN
4	60	0.28	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 392 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2ZKT · Structure of PH0037 protein from Pyrococcus horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
O57742 · AlphaFold monomer V2.0 prediction for 2,3-bisphosphoglycerate- independent… · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O57742
Elsewhere: RCSB PDB 2ZKT · PDBe 2ZKT · UniProt O57742

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