Research workbench
Crystal structure of the MUS81-EME1 complex
Analyse Crystal structure of the MUS81-EME1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZIW
- Type
- protein
- Length
- 499 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MUS81 protein; Crossover junction endonuclease EME1
- EC
- 3.1.22.-
- UniProt
- Q6GML8, Q96AY2
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MUS81 protein | protein | 271 | 41% helix, 16% strand | Q6GML8 |
| B | Crossover junction endonuclease EME1 (EC 3.1.22.-) | protein | 228 | 40% helix, 7% strand | Q96AY2 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 425 | 0.68 | 0.80 | 51 | empty |
| 2 | 442 | 0.64 | 0.77 | 59 | empty |
| 3 | 157 | 0.52 | 0.79 | 21 | empty |
| 4 | 167 | 0.47 | 0.76 | 33 | empty |
| 5 | 101 | 0.36 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 3544 Ų buried · 47 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GML8
- Every structure of UniProt Q96AY2
- Elsewhere: RCSB PDB 2ZIW · PDBe 2ZIW · UniProt Q6GML8 · UniProt Q96AY2
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