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Crystal structure of the N-terminal kinase domain of human RSK1 bound to staurosporine

Analyse Crystal structure of the N-terminal kinase domain of human RSK1 bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Z7R
Type: protein
Length: 265 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribosomal protein S6 kinase alpha-1
EC: 2.7.11.1
UniProt: Q15418
Ligands: STU
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)	protein	265	35% helix, 17% strand	Q15418

Ligands and binding sites

STU · Staurosporine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	456	0.70	0.80	46	STU
2	59	0.45	0.83	15	empty
3	53	0.25	0.73	17	empty

Compared structures

2Z7R · Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine · the same entry in another collection · chain A against A, TM-score 1.00
Q15418 · AlphaFold monomer V2.0 prediction for ribosomal protein S6 kinase alpha-1 (Q15418) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15418
Elsewhere: RCSB PDB 2Z7R · PDBe 2Z7R · UniProt Q15418

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