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Crystal structure of chromatin protein alba from hyperthermophilic archaeon pyrococcus horikoshii

Analyse Crystal structure of chromatin protein alba from hyperthermophilic archaeon… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Z7C
Type: protein
Length: 359 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA/RNA-binding protein alba
UniProt: O74101
Ligands: ARG
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	DNA/RNA-binding protein alba	protein	89	33% helix, 39% strand	O74101
D	DNA/RNA-binding protein alba	protein	92	32% helix, 41% strand	O74101

Ligands and binding sites

ARG · Arginine · ligand · 2 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1100	0.74	0.77	102	empty
2	61	0.30	0.76	18	empty

Interfaces

4 interfaces between chains.

C–D · 751 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 692 Å² buried · 10 hydrogen bonds · protein-protein
B–D · 533 Å² buried · 3 hydrogen bonds · protein-protein
A–D · 59 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2Z7C · Crystal structure of chromatin protein alba from hyperthermophilic archaeon pyrococcus… · the same entry in another collection · chain B against B, TM-score 1.00
O74101 · AlphaFold monomer V2.0 prediction for DNA/RNA-binding protein alba (O74101) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O74101
Elsewhere: RCSB PDB 2Z7C · PDBe 2Z7C · UniProt O74101

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