Research workbench

Complex structure of lf-transferase and leucine

Analyse Complex structure of lf-transferase and leucine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Z3P
Type: protein
Length: 463 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: LEUCYL/PHENYLALANYL-tRNA-protein transferase
EC: 2.3.2.6
UniProt: P0A8P1
Ligands: LEU
Pockets: 3 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	LEUCYL/PHENYLALANYL-tRNA-protein transferase (EC 2.3.2.6)	protein	232	34% helix, 27% strand	P0A8P1
B	LEUCYL/PHENYLALANYL-tRNA-protein transferase (EC 2.3.2.6)	protein	231	34% helix, 26% strand	P0A8P1

Ligands and binding sites

LEU · Leucine · ligand · 2 copies · chains A, B
TAR · D(-)-tartaric acid · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	535	0.81	0.87	56	empty
2	301	0.67	0.82	35	LEU
3	347	0.67	0.80	36	LEU

Interfaces

1 interface between chains.

A–B · 910 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

2Z3P · complex structure of LF-transferase and leucine · the same entry in another collection · chain B against B, TM-score 1.00
P0A8P1 · AlphaFold monomer V2.0 prediction for LEUCYL/PHENYLALANYL-tRNA-- protein transferase… · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A8P1
Elsewhere: RCSB PDB 2Z3P · PDBe 2Z3P · UniProt P0A8P1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.