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Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with N-(5'-phosphopyridoxyl)-L-leucine), from thermus thermophilus HB27
Analyse Crystal structure of lysn, alpha-aminoadipate aminotransferase (complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Z1Y
- Type
- protein
- Length
- 783 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-aminodipate aminotransferase
- EC
- 2.6.1.39
- UniProt
- Q72LL6
- Ligands
- LEU, PLP
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-aminodipate aminotransferase (EC 2.6.1.39) | protein | 389 | 48% helix, 15% strand | Q72LL6 |
| B | Alpha-aminodipate aminotransferase (EC 2.6.1.39) | protein | 394 | 48% helix, 15% strand | Q72LL6 |
Ligands and binding sites
- LEU · Leucine · ligand · 2 copies · chains A, B
- PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.78 | 0.97 | 26 | LEU, PLP |
| 2 | 113 | 0.77 | 0.96 | 27 | LEU, PLP |
| 3 | 97 | 0.66 | 0.91 | 19 | empty |
| 4 | 280 | 0.57 | 0.77 | 47 | empty |
| 5 | 138 | 0.39 | 0.73 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 3912 Ų buried · 63 hydrogen bonds · protein-protein
Compared structures
- 2Z1Y · Crystal structure of LysN, alpha-aminoadipate aminotransferase (complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q72LL6 · AlphaFold monomer V2.0 prediction for 2-aminoadipate transaminase (Q72LL6) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72LL6
- Elsewhere: RCSB PDB 2Z1Y · PDBe 2Z1Y · UniProt Q72LL6
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