Research workbench
Crystal structure of RNA-binding domain of NS1 from influenza a virus A/CROW/KYOTO/T1/2004(H5N1)
Analyse Crystal structure of RNA-binding domain of NS1 from influenza a virus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Z0A
- Type
- protein
- Length
- 287 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nonstructural protein 1
- UniProt
- Q5H7I4
- Ligands
- GLY
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Nonstructural protein 1 | protein | 72 | 82% helix, 0% strand | Q5H7I4 |
| B | Nonstructural protein 1 | protein | 71 | 82% helix, 0% strand | Q5H7I4 |
| C | Nonstructural protein 1 | protein | 72 | 82% helix, 0% strand | Q5H7I4 |
Ligands and binding sites
- GLY · Glycine · ligand · 4 copies · chains A, C, D
- SIN · Succinic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 507 | 0.65 | 0.77 | 50 | empty |
| 2 | 171 | 0.62 | 0.84 | 19 | GLY |
| 3 | 173 | 0.61 | 0.83 | 19 | SIN |
| 4 | 69 | 0.37 | 0.77 | 13 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1300 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1236 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 251 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2Z0A · Crystal structure of RNA-binding domain of NS1 from influenza A virus… · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5H7I4
- Elsewhere: RCSB PDB 2Z0A · PDBe 2Z0A · UniProt Q5H7I4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.