Research workbench
Solution structure of the shp-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
Analyse Solution structure of the shp-1 C-terminal SH2 domain complexed with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2YU7
- Type
- protein
- Length
- 133 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 6; Natural killer group 2A
- EC
- 3.1.3.48
- UniProt
- P29350, P26715
Structure
solution nmr · 2 distinct chains · 16% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) | protein | 118 | 18% helix, 30% strand | P29350 |
| B | Natural killer group 2A | protein | 15 | 0% helix, 7% strand | P26715 |
Interfaces
1 interface between chains.
- A–B · 662 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2YU7 · Solution structure of the SHP-1 C-terminal SH2 domain complexed with a… · the same entry in another collection · chain A against A, TM-score 1.00
- P29350 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 6… · a predicted model of the same protein · chain A against A, TM-score 0.86
- P26715 · AlphaFold monomer V2.0 prediction for NKG2-A/NKG2-B type II integral membrane protein… · a predicted model of the same protein · chain B against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29350
- Every structure of UniProt P26715
- Elsewhere: RCSB PDB 2YU7 · PDBe 2YU7 · UniProt P29350 · UniProt P26715
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