UniProt P29350
Tyrosine-protein phosphatase non-receptor type 6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (UniProt P29350): 25 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P29350
- Protein
- Tyrosine-protein phosphatase non-receptor type 6
- Experimental structures
- 25
- Predicted models
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
26 records of P29350 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FPR | Crystal structure of the complex formed between the catalytic domain of shp-1 and an in vitro… | x-ray diffraction | A | — | — |
| 1FPR | Crystal structure of the complex formed between the catalytic domain of shp-1 and an in vitro… | x-ray diffraction | A | — | — |
| 1GWZ | Crystal structure of the catalytic domain of the protein tyrosine phosphatase shp-1 | x-ray diffraction | A | — | — |
| 1GWZ | Crystal structure of the catalytic domain of the protein tyrosine phosphatase shp-1 | x-ray diffraction | A | — | — |
| 1X6C | Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 | solution nmr | A | — | — |
| 1X6C | Solution structures of the SH2 domain of human protein-tyrosine phosphatase shp-1 | solution nmr | A | — | — |
| 2B3O | Crystal structure of human tyrosine phosphatase SHP-1 | x-ray diffraction | A | — | — |
| 2B3O | Crystal structure of human tyrosine phosphatase shp-1 | x-ray diffraction | A | — | — |
| 2RMX | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated… | solution nmr | A | — | — |
| 2RMX | Solution structure of the shp-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated… | solution nmr | A | — | — |
| 2YU7 | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated… | solution nmr | A | — | — |
| 2YU7 | Solution structure of the shp-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated… | solution nmr | A | — | — |
| 3PS5 | Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1 | x-ray diffraction | A | — | — |
| 3PS5 | Crystal structure of the full-length human protein tyrosine phosphatase shp-1 | x-ray diffraction | A | — | — |
| 4GRY | Crystal structure of SHP1 catalytic domain with SO4 | x-ray diffraction | A | — | — |
| 4GRY | Crystal structure of SHP1 catalytic domain with SO4 | x-ray diffraction | A | — | — |
| 4GRZ | Crystal structure of SHP1 catalytic domain with PO4 | x-ray diffraction | A | — | — |
| 4GRZ | Crystal structure of SHP1 catalytic domain with PO4 | x-ray diffraction | A | — | — |
| 4GS0 | Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide | x-ray diffraction | A, B | — | — |
| 4GS0 | Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide | x-ray diffraction | A, B | — | — |
| 4HJP | SHP-1 catalytic domain WPD loop open | x-ray diffraction | A | — | — |
| 4HJP | Shp-1 catalytic domain wpd loop open | x-ray diffraction | A | — | — |
| 4HJQ | SHP-1 catalytic domain WPD loop closed | x-ray diffraction | A, B | — | — |
| 4HJQ | Shp-1 catalytic domain wpd loop closed | x-ray diffraction | A, B | — | — |
| 6SM5 | MBC/SHP1-C-SH2 complex | x-ray diffraction | A | — | — |
| P29350 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 6 (P29350) | predicted | A | — | 6 (best 0.67) |
Experiment against prediction
- 4GS0 chain B against the predicted model P29350: TM-score 0.99, RMSD 0.62 Å
- 4GS0 chain B against the predicted model P29350: TM-score 0.99, RMSD 0.62 Å
- 3PS5 chain A against the predicted model P29350: TM-score 0.99, RMSD 0.96 Å
- 3PS5 chain A against the predicted model P29350: TM-score 0.99, RMSD 0.96 Å
- 4HJQ chain A against the predicted model P29350: TM-score 0.99, RMSD 0.79 Å
- 4HJQ chain A against the predicted model P29350: TM-score 0.99, RMSD 0.79 Å
- 4GRZ chain A against the predicted model P29350: TM-score 0.99, RMSD 0.80 Å
- 4GRZ chain A against the predicted model P29350: TM-score 0.99, RMSD 0.80 Å
- 6SM5 chain A against the predicted model P29350: TM-score 0.96, RMSD 0.94 Å
- 4GRY chain A against the predicted model P29350: TM-score 0.95, RMSD 1.80 Å
Elsewhere
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