Research workbench
Crystal structure of the TPR2A domain of hop in complex with the HSP90 peptide meevd
Analyse Crystal structure of the TPR2A domain of hop in complex with the HSP90 peptide… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ELR
- Type
- protein
- Length
- 133 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TPR2A-domain of hop; HSP90-peptide meevd
- UniProt
- P31948
- Ligands
- ACE, NI
- Pockets
- 1 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TPR2A-domain of hop | protein | 128 | 84% helix, 0% strand | P31948 |
| B | HSP90-peptide meevd | protein | 5 | 0% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 157 | 0.48 | 0.77 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 510 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 1ELR · Crystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVD · the same entry in another collection · chain A against A, TM-score 1.00
- P31948 · AlphaFold monomer V2.0 prediction for stress-induced-phosphoprotein 1 (P31948) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31948
- Elsewhere: RCSB PDB 1ELR · PDBe 1ELR · UniProt P31948
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