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Bovine purine nucleoside phosphorylase complexed with hypoxanthine and sulfate

Analyse Bovine purine nucleoside phosphorylase complexed with hypoxanthine and sulfate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1A9R
Type: protein
Length: 282 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Purine nucleoside phosphorylase
EC: 2.4.2.1
UniProt: P55859
Ligands: HPA, SO4
Pockets: 1 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Purine nucleoside phosphorylase (EC 2.4.2.1)	protein	282	35% helix, 25% strand	P55859

Ligands and binding sites

HPA · Hypoxanthine · ligand · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	416	0.69	0.81	49	SO4, HPA

Compared structures

1A9R · Bovine purine nucleoside phosphorylase complexed with hypoxanthine and sulfate · the same entry in another collection · chain A against A, TM-score 1.00
P55859 · AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase (P55859) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55859
Elsewhere: RCSB PDB 1A9R · PDBe 1A9R · UniProt P55859

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