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Pentameric ligand gated ion channel elic mutant F246A

Analyse Pentameric ligand gated ion channel elic mutant F246A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2YKS
Type: protein
Length: 3,060 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cys-loop ligand-gated ion channel
UniProt: P0C7B7
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J	Cys-loop ligand-gated ion channel	protein	306	27% helix, 32% strand	P0C7B7

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	316	0.85	0.95	36	empty
2	309	0.84	0.95	39	empty
3	999	0.83	0.83	109	empty
4	987	0.83	0.84	101	empty
5	1032	0.82	0.83	106	empty

Interfaces

21 interfaces between chains.

A–E · 2611 Å² buried · 24 hydrogen bonds · protein-protein
H–I · 2592 Å² buried · 24 hydrogen bonds · protein-protein
F–J · 2587 Å² buried · 22 hydrogen bonds · protein-protein
C–D · 2585 Å² buried · 22 hydrogen bonds · protein-protein
B–C · 2579 Å² buried · 25 hydrogen bonds · protein-protein

Compared structures

2YKS · Pentameric ligand gated ion channel elic mutant F246A · the same entry in another collection · chain J against J, TM-score 1.00
P0C7B7 · AlphaFold monomer V2.0 prediction for cys-loop ligand-gated ion channel (P0C7B7) · a predicted model of the same protein · chain J against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0C7B7
Elsewhere: RCSB PDB 2YKS · PDBe 2YKS · UniProt P0C7B7

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