Research workbench
Crystal structure of the allosteric-defective chaperonin groel E434K mutant
Analyse Crystal structure of the allosteric-defective chaperonin groel E434K mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2YEY
- Type
- protein
- Length
- 7,336 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 60 kda chaperonin
- UniProt
- P0A6F5
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N | 60 kda chaperonin | protein | 524 | 51% helix, 19% strand | P0A6F5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.79 | 0.81 | 112 | empty |
| 2 | 1082 | 0.79 | 0.80 | 98 | empty |
| 3 | 1008 | 0.79 | 0.80 | 109 | empty |
| 4 | 994 | 0.78 | 0.80 | 108 | empty |
| 5 | 1055 | 0.78 | 0.80 | 108 | empty |
Interfaces
28 interfaces between chains.
- K–L · 1923 Ų buried · 28 hydrogen bonds · protein-protein
- D–E · 1826 Ų buried · 19 hydrogen bonds · protein-protein
- F–G · 1808 Ų buried · 24 hydrogen bonds · protein-protein
- M–N · 1801 Ų buried · 19 hydrogen bonds · protein-protein
- A–G · 1791 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 2YEY · Crystal structure of the allosteric-defective chaperonin GroEL E434K mutant · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6F5
- Elsewhere: RCSB PDB 2YEY · PDBe 2YEY · UniProt P0A6F5
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