Research workbench
Chromatin remodeling factor ISW1A(DEL_ATPASE) in DNA complex
Analyse Chromatin remodeling factor ISW1A(DEL_ATPASE) in DNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Y9Z
- Type
- protein + DNA
- Length
- 990 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Imitation switch protein 1 (DEL_ATPASE); Iswi one complex protein 3; I-DNA/E-DNA
- UniProt
- P38144, P43596
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 6 distinct chains · 47% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Imitation switch protein 1 (DEL_ATPASE) | protein | 287 | 57% helix, 0% strand | P38144 |
| B | Iswi one complex protein 3 | protein | 595 | 43% helix, 5% strand | P43596 |
| C | I-DNA/E-DNA | dna | 31 | — | — |
| D | I-DNA/E-DNA | dna | 31 | — | — |
| E | I-DNA/E-DNA | dna | 23 | — | — |
| F | I-DNA/E-DNA | dna | 23 | — | — |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 927 | 0.77 | 0.80 | 70 | empty |
| 2 | 63 | 0.73 | 0.98 | 17 | empty |
| 3 | 55 | 0.72 | 0.98 | 18 | empty |
| 4 | 61 | 0.70 | 0.97 | 23 | empty |
| 5 | 284 | 0.69 | 0.84 | 32 | empty |
Interfaces
9 interfaces between chains.
- A–B · 2883 Ų buried · 46 hydrogen bonds · protein-protein
- C–D · 1469 Ų buried · 140 hydrogen bonds · nucleic-nucleic
- E–F · 1065 Ų buried · 98 hydrogen bonds · nucleic-nucleic
- A–D · 357 Ų buried · 2 hydrogen bonds · protein-nucleic
- B–F · 278 Ų buried · 3 hydrogen bonds · protein-nucleic
Compared structures
- 2Y9Z · Chromatin Remodeling Factor ISW1a(del_ATPase) in DNA complex · the same entry in another collection · chain F against F, TM-score 1.00
- P43596 · AlphaFold monomer V2.0 prediction for iswi one complex protein 3 (P43596) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P38144 · AlphaFold monomer V2.0 prediction for iswi chromatin-remodeling complex ATPase ISW1… · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38144
- Every structure of UniProt P43596
- Elsewhere: RCSB PDB 2Y9Z · PDBe 2Y9Z · UniProt P38144 · UniProt P43596
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