UniProt P38144
ISWI chromatin-remodeling complex ATPase ISW1 (P38144)
ISWI chromatin-remodeling complex ATPase ISW1 (UniProt P38144), EC 3.6.4.-: 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P38144
- Protein
- ISWI chromatin-remodeling complex ATPase ISW1
- EC
- 3.6.4.-
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 21 · 3 records with a druggable one
Structures
12 records of P38144 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Y9Y | Chromatin Remodeling Factor ISW1a(del_ATPase) | x-ray diffraction | A | — | — |
| 2Y9Y | Chromatin remodeling factor ISW1A(DEL_ATPASE) | x-ray diffraction | A | — | — |
| 2Y9Z | Chromatin Remodeling Factor ISW1a(del_ATPase) in DNA complex | x-ray diffraction | A | — | — |
| 2Y9Z | Chromatin remodeling factor ISW1A(DEL_ATPASE) in DNA complex | x-ray diffraction | A | — | — |
| 6IRO | The crosslinked complex of iswi-nucleosome in the ADP-bound state | electron microscopy | L | ADP | — |
| 6JYL | The crosslinked complex of ISWI-nucleosome in the ADP.BeF-bound state | electron microscopy | K | ADP, BEF, MG | — |
| 6JYL | The crosslinked complex of iswi-nucleosome in the ADP.BEF-bound state | electron microscopy | K | ADP, BEF, MG | — |
| 6K1P | The complex of ISWI-nucleosome in the ADP.BeF-bound state | electron microscopy | K | BEF, MG, ADP | 7 (best 0.83) |
| 6K1P | The complex of iswi-nucleosome in the ADP.BEF-bound state | electron microscopy | K | BEF, MG, ADP | — |
| 7X3T | Cryo-EM structure of ISW1a-dinucleosome | electron microscopy | V | ADP, BEF, MG | 5 (best 0.86) |
| 7X3W | Cryo-EM structure of ISW1-N1 nucleosome | electron microscopy | K | ADP, BEF, MG | 9 (best 0.83) |
| P38144 | AlphaFold monomer V2.0 prediction for iswi chromatin-remodeling complex ATPase ISW1 (P38144) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7X3W chain K against the predicted model P38144: TM-score 0.91, RMSD 2.65 Å
- 6JYL chain K against the predicted model P38144: TM-score 0.91, RMSD 2.68 Å
- 6JYL chain K against the predicted model P38144: TM-score 0.91, RMSD 2.68 Å
- 6K1P chain K against the predicted model P38144: TM-score 0.90, RMSD 2.65 Å
- 6K1P chain K against the predicted model P38144: TM-score 0.90, RMSD 2.65 Å
- 2Y9Y chain A against the predicted model P38144: TM-score 0.85, RMSD 2.85 Å
- 2Y9Y chain A against the predicted model P38144: TM-score 0.85, RMSD 2.85 Å
- 6IRO chain L against the predicted model P38144: TM-score 0.81, RMSD 3.93 Å
- 2Y9Z chain A against the predicted model P38144: TM-score 0.81, RMSD 3.19 Å
- 2Y9Z chain A against the predicted model P38144: TM-score 0.81, RMSD 3.19 Å
Elsewhere
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