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Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of dictyostelium myosin-2

Analyse Structural basis for the allosteric interference of myosin function by mutants… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Y9E
Type: protein
Length: 758 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin-2
EC: 3.6.4.1
UniProt: P08799
Pockets: 16 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Myosin-2 (EC 3.6.4.1)	protein	758	31% helix, 12% strand	P08799

Pockets

16 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1195	0.81	0.83	94	empty
2	856	0.81	0.83	80	empty
3	112	0.72	0.93	32	empty
4	402	0.71	0.82	54	empty
5	455	0.70	0.81	49	empty

Compared structures

2Y9E · Structural basis for the allosteric interference of myosin function by mutants G680A and… · the same entry in another collection · chain X against X, TM-score 1.00
P08799 · AlphaFold monomer V2.0 prediction for myosin-2 heavy chain (P08799) · a predicted model of the same protein · chain X against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08799
Elsewhere: RCSB PDB 2Y9E · PDBe 2Y9E · UniProt P08799

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