Research workbench
Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of dictyostelium myosin-2
Analyse Structural basis for the allosteric interference of myosin function by mutants… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Y8I
- Type
- protein
- Length
- 758 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-2 heavy chain
- EC
- 3.6.4.1
- UniProt
- P08799
- Ligands
- ADP, MG
- Pockets
- 12 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Myosin-2 heavy chain (EC 3.6.4.1) | protein | 758 | 35% helix, 11% strand | P08799 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 804 | 0.76 | 0.80 | 56 | empty |
| 2 | 630 | 0.76 | 0.82 | 71 | ADP |
| 3 | 1120 | 0.75 | 0.78 | 93 | empty |
| 4 | 255 | 0.62 | 0.81 | 31 | empty |
| 5 | 50 | 0.47 | 0.85 | 17 | empty |
Compared structures
- 2Y8I · Structural basis for the allosteric interference of myosin function by mutants G680A and… · the same entry in another collection · chain X against X, TM-score 1.00
- P08799 · AlphaFold monomer V2.0 prediction for myosin-2 heavy chain (P08799) · a predicted model of the same protein · chain X against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08799
- Elsewhere: RCSB PDB 2Y8I · PDBe 2Y8I · UniProt P08799
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