Research workbench
Aplysia californica achbp in apo state
Analyse Aplysia californica achbp in apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Y7Y
- Type
- protein
- Length
- 1,010 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Soluble acetylcholine receptor
- UniProt
- Q8WSF8
- Pockets
- 19 · best druggability 0.65
Structure
x-ray diffraction · 4 distinct chains · 9% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Soluble acetylcholine receptor | protein | 203 | 8% helix, 51% strand | Q8WSF8 |
| B, C | Soluble acetylcholine receptor | protein | 201 | 9% helix, 51% strand | Q8WSF8 |
| D | Soluble acetylcholine receptor | protein | 200 | 9% helix, 53% strand | Q8WSF8 |
| E | Soluble acetylcholine receptor | protein | 205 | 9% helix, 51% strand | Q8WSF8 |
Pockets
19 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 515 | 0.65 | 0.77 | 56 | empty |
| 2 | 497 | 0.64 | 0.76 | 62 | empty |
| 3 | 489 | 0.63 | 0.76 | 52 | empty |
| 4 | 413 | 0.60 | 0.76 | 54 | empty |
| 5 | 397 | 0.60 | 0.76 | 48 | empty |
Interfaces
5 interfaces between chains.
- D–E · 1265 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 1265 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 1260 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1248 Ų buried · 17 hydrogen bonds · protein-protein
- A–E · 1247 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2Y7Y · Aplysia californica achbp in apo state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WSF8
- Elsewhere: RCSB PDB 2Y7Y · PDBe 2Y7Y · UniProt Q8WSF8
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