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Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of dictyostelium myosin-2

Analyse Structural basis for the allosteric interference of myosin function by mutants… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Y0R
Type: protein
Length: 758 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin-2 heavy chain
UniProt: P08799
Pockets: 9 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Myosin-2 heavy chain	protein	758	36% helix, 11% strand	P08799

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1006	0.81	0.82	88	empty
2	994	0.80	0.81	103	empty
3	241	0.63	0.82	40	empty
4	169	0.58	0.82	30	empty
5	163	0.56	0.81	21	empty

Compared structures

2Y0R · Structural basis for the allosteric interference of myosin function by mutants G680A and… · the same entry in another collection · chain X against X, TM-score 1.00
P08799 · AlphaFold monomer V2.0 prediction for myosin-2 heavy chain (P08799) · a predicted model of the same protein · chain X against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08799
Elsewhere: RCSB PDB 2Y0R · PDBe 2Y0R · UniProt P08799

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